Preheat the oven to 350 degrees. Spray a 13 x 9 baking dish with cooking spray. Cook pasta in salted water according to package direction.
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Meanwhile, melt the butter in a medium saucepan over medium heat. Stir in flour and cook, stirring often, for 3 to 4 minutes, until golden brown.
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Whisk in milk in slowly until well combined and cook, stirring often, until slightly thickened, about 8 minutes.
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Reduce heat to medium-low and stir in the shredded cheddar and gouda or gruyere cheese. Cook until melted, then add in Dijon mustard, salt, pepper, cayenne, and Worcestershire sauce. Stir until well combined.
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When pasta is cooked, drain and toss with cheese sauce and cubed cheddar cheese. Transfer to prepared pan.
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Melt butter in a small saucepan. Toss with crumbs and sprinkle on top of pasta. Bake for 35 minutes. Allow to cool for 10 minutes before serving.
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